Stadtfeld, Matthias

Publications

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selected publications

Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells. Stem cell reports. 2025 Academic Article GET IT
Coordinated repression of totipotency-associated gene loci by histone methyltransferase EHMT2 through binding to LINE-1 regulatory elements. 2024 GET IT
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naïve pluripotent stem cells. 2024 GET IT
Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm. 2024 GET IT
Juvenile hormones direct primordial germ cell migration to the embryonic gonad. Current biology : CB. 2024 Academic Article GET IT
Times cited: 13
3D Enhancer-promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages. Nature structural & molecular biology. 2023 Academic Article GET IT
The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes. Cell reports. 2022 Academic Article GET IT
Times cited: 11
A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus. Developmental cell. 2021 Academic Article GET IT
Times cited: 19
Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency. Stem cell reports. 2020 Academic Article GET IT
Times cited: 8
A Susceptibility Locus on Chromosome 13 Profoundly Impacts the Stability of Genomic Imprinting in Mouse Pluripotent Stem Cells. Cell reports. 2020 Academic Article GET IT
Times cited: 13
EpiMethylTag: simultaneous detection of ATAC-seq or ChIP-seq signals with DNA methylation. Genome biology. 2019 Academic Article GET IT
Times cited: 29
KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks. Nature cell biology. 2019 Academic Article GET IT
Times cited: 127
Evaluation of Stuart et al.: Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell stem cell. 2019 Comment GET IT
Cellular trajectories and molecular mechanisms of iPSC reprogramming. Current opinion in genetics & development. 2018 Review GET IT
Times cited: 45
Nascent Induced Pluripotent Stem Cells Efficiently Generate Entirely iPSC-Derived Mice while Expressing Differentiation-Associated Genes. Cell reports. 2018 Academic Article GET IT
Times cited: 9
The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Nature cell biology. 2017 Academic Article GET IT
Times cited: 42
Probabilistic Modeling of Reprogramming to Induced Pluripotent Stem Cells. Cell reports. 2016 Academic Article GET IT
Times cited: 9
Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Nature cell biology. 2016 Academic Article GET IT
Times cited: 56
A reporter model to visualize imprinting stability at the Dlk1 locus during mouse development and in pluripotent cells. Development (Cambridge, England). 2016 Academic Article GET IT
Times cited: 13
Co-repressor CBFA2T2 regulates pluripotency and germline development. Nature. 2016 Academic Article GET IT
Times cited: 56
The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 2015 Academic Article GET IT
Times cited: 212
F-class cells: new routes and destinations for induced pluripotency. Cell stem cell. 2015 Academic Article GET IT
Times cited: 6
Combinatorial modulation of signaling pathways reveals cell-type-specific requirements for highly efficient and synchronous iPSC reprogramming. Stem cell reports. 2014 Academic Article GET IT
Times cited: 58
Histone variant H2A.X deposition pattern serves as a functional epigenetic mark for distinguishing the developmental potentials of iPSCs. Cell stem cell. 2014 Academic Article GET IT
Times cited: 44
Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming. Nature communications. 2014 Academic Article GET IT
Times cited: 66
Panning data for gold: the search for master regulators of cell fate. Nature methods. 2013 Comment GET IT
Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming. Cell stem cell. 2013 Academic Article GET IT
Times cited: 171
Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state. Cell reports. 2013 Academic Article GET IT
Times cited: 76
A molecular roadmap of reprogramming somatic cells into iPS cells. Cell. 2012 Academic Article GET IT
Times cited: 708
Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. Cell stem cell. 2012 Academic Article GET IT
Times cited: 235
Blood cell fate changes without cell cycle transition. Cell cycle (Georgetown, Tex.). 2012 Comment GET IT
Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nature genetics. 2012 Academic Article GET IT
Times cited: 248
Induced pluripotency: history, mechanisms, and applications. Genes & development. 2010 Review GET IT
Times cited: 651
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nature biotechnology. 2010 Academic Article GET IT
Times cited: 1009
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature. 2010 Academic Article GET IT
Times cited: 674
Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture. Blood. 2010 Academic Article GET IT
Times cited: 52
Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood. 2010 Academic Article GET IT
Times cited: 370
A reprogrammable mouse strain from gene-targeted embryonic stem cells. Nature methods. 2009 Academic Article GET IT
Times cited: 163
Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Nature genetics. 2009 Academic Article GET IT
Times cited: 364
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature. 2009 Academic Article GET IT
Times cited: 725
Without a trace? PiggyBac-ing toward pluripotency. Nature methods. 2009 Comment GET IT
Times cited: 11
Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem cells (Dayton, Ohio). 2009 Academic Article GET IT
Times cited: 549
Fibroblast-derived induced pluripotent stem cells show no common retroviral vector insertions. Stem cells (Dayton, Ohio). 2009 Academic Article GET IT
Times cited: 56
Heterogeneity of embryonic and adult stem cells. Cell stem cell. 2008 Review GET IT
Times cited: 278
Induced pluripotent stem cells generated without viral integration. Science (New York, N.Y.). 2008 Academic Article GET IT
Times cited: 1398
Reprogramming of pancreatic beta cells into induced pluripotent stem cells. Current biology : CB. 2008 Academic Article GET IT
Times cited: 355
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell stem cell. 2008 Academic Article GET IT
Times cited: 688
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell stem cell. 2007 Academic Article GET IT
Times cited: 1477
CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation. Experimental hematology. 2007 Academic Article GET IT
Times cited: 67
Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Developmental cell. 2006 Academic Article GET IT
Times cited: 238
Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors. Immunity. 2006 Academic Article GET IT
Times cited: 299
Identification of interventricular septum precursor cells in the mouse embryo. Developmental biology. 2006 Academic Article GET IT
Times cited: 28
Determinants of lymphoid-myeloid lineage diversification. Annual review of immunology. 2006 Review GET IT
Times cited: 219
Fluorescent protein-cell labeling and its application in time-lapse analysis of hematopoietic differentiation. Methods in molecular medicine. 2005 Review GET IT
Times cited: 21
Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing. Development (Cambridge, England). 2004 Academic Article GET IT
Times cited: 203
Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential. Immunity. 2003 Academic Article GET IT
Times cited: 158

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Research

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Funding awarded

Dissecting genetic determinants of epigenetic instability in pluripotent stem cells awarded by National Institute of General Medical Sciences Principal Investigator 2022 - 2026
A human embryonic stem cell-based platform to understand the association between neuronal maturation and neurodevelopmental disease awarded by Tri-Institutional Stem Cell Initiative (Weill Cornell) Principal Investigator 2023 - 2025
Novel approaches to explore principles of epigenetic gene regulation during neurogenesis awarded by Tri-Institutional Stem Cell Initiative (Weill Cornell) Principal Investigator 2020 - 2022

Organizational principles and functional role of 3D enhancer hubs in cell fate decisions Co-Investigator 2020 - 2025

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Background

education and training

M.S., University of Heidelberg (Germany) 2000
Ph.D., Albert Einstein College of Medicine of Yeshiva University 2005

Contact

full name

Matthias Stadtfeld

primary email

[email protected]

VIVO Weill Cornell Medical College

Matthias Stadtfeld Associate Professor of Cell Biology in Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email